Dr Anil Kumar Pasupulati
Assistant Professor, Department of Biochemistry
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Anil Kumar Pasupulati is a faculty at Dept. Biochemistry, School of Life Sciences, University of Hyderabad. Anil's research emphasis has been on understanding the significant insights about the glomerular filtration barrier in health and diseases such as diabetes, obesity, and chronic kidney disease (CKD) of Unknown origin. CKD affects more than 10% of the world's population, and 90% of all these cases are glomerular diseases.
Employing human glomerular podocytes as a model, Anil's laboratory identified that transcription factors such as ZEB2, WT1, and NICD1 over-express in the settings of diabetes and obesity and re-activate certain embryological events (such as Notch signaling and Epithelial-mesenchymal transition) in adult podocytes, thus contribute to the impaired kidney function. Anil lab also demonstrated that stabilization of HIF1⍺ results in calcium influx into podocytes, which eventually results in the compromised cytoskeletal architecture of podocytes, which eventually manifests in proteinuria.
Research Interests
Diabetic nephropathy, Chronic Kidney Disease, Epithelial-Mesenchymal Transition, and Bioinformatics of Kidney.
Postdoctoral & Fellowship Appointments
2/2012 - 7/2014
DST-INSPIRE Faculty,
National Institute of Nutrition, India.
8/2008 - 1/2012
Post-doctoral fellow, University of Michigan,
Ann Arbor, USA.
9/2007-7/2008
Post-doctoral fellow, University of California, Irvine, USA
Anil Received INSPIRE Faculty (1st Batch) Award from DST in Nov 2011 and Joined at Dept. Biochemistry, OU-Hyd in Jan 2012 and transferred to NIN-ICMR in April 2013 and served till July 2013. He was doing both teaching and research.
Anil joined as postdoctoral fellow in the laboratory of Prof. Ram Menon, Director of Dept. of Pediatric Endocrinolgy, University of Michigan in Aug 2008. Anil's major research project was 'Investigation of Non-canonical function of growth hormone on glomerular podocytes'.
Anil joined the laboratory of Dr. Adriana Briscoe's lab right after submission of Ph.D. thesis. In her lab, Anil was associated with characterizing the ability of Butterfly rhodapsin to enable color vision to those creatures using transgenic Drosophila.
Education
2002-2008
PhD Biochemistry,
NIN-ICMR (Osmania University),
Hyderabad, India
2000-2002
M.Sc. Biochemistry, Andhra University, Visakhapatnam, India
1997-2002
B.Sc. Microbiology, Acharya Nagarjuna University, Guntur, India.
Anil's Ph.D. title was 'Structure, Function, and Expression of Alpha-crystallin in Diabetic Condition'.
Alpha-crystallin is predoimant protein present in the vertibrate eye lens. ,
Recognition & Awards
Peer-reviewing Activities
2022
Associate Editor,
Frontiers Medicine-Nephrology.
2020
Yellapragada Gold Medal from
BIO-NEST-UoH.
2018
DHR-INDIA Long-term Fellowship.
2016
ERA-EDTA Travel Award
to participate in the International Conference on Podocytes, Israel.
2014
Wood-Whelan Research Fellowship.
2012
FASEB Travel Award,
Snowmass Village, CO, USA.
2012
DBT-Wellcome Trust Early Awardee
(Not Availed).
2011
DST-INSPIRE Faculty Fellowship Awardee.
2010
Endocrine Trainee and Travel Award,
ENDO, San Diego, CA.
2022
Chancellor's Award 2022,
University of Hyderabad.
2007
K.V. Rao Scientific Research Award
in Biological Sciences.
Reviewer for J Biol Chem, Molecular Therapy, Diabetologia, Endocrinology,
J Cell Physiology, J Cell Biochem, J Cell Mol Med, Frontiers.
Reviewer for Grants: Polish Science Academy, UKUI, SERB-India.