Venkata Atreya Sai Paturi

Atreya's research emphasis has been on understanding the significant insights about the glomerular filtration barrier in health and diseases such as diabetic kidney disease (DKD) of unknown origin. Diabetes affects more than 10% of the world's population and is characterized by hyperglycemia either with the absence of insulin or its receptor. Dr Anil's lab and others have shown that diabetes is presented with elevated Growth Hormone, a characteristic feature observed in 30% of the type 1 diabetes population. And employing human glomerular podocytes as a non-canonical target of growth hormone he intends to investigate the source of calcium influx into podocytes, which eventually results in the compromised cytoskeletal architecture, ultimately manifesting in proteinuria.
He employs multidisciplinary approaches to understanding:

1) Investigate the intracellular distribution of calcium in podocytes of DKD and

2) Elucidate the role of calcium dynamics in the mitochondrial biology of DKD.

He extensively utilizes cell and molecular biology tools, confocal microscopy, electrophysiology, genomics approaches and in vivo animal models for addressing the research problems.